Albumin fibrillization induces apoptosis via integrin/FAK/Akt pathway |
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| Authors: | Chun-Yung Huang Chi-Ming Liang Chiao-Li Chu Shu-Mei Liang |
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| Institution: | (1) Institute of Biotechnology, National Cheng Kung University, Tainan, Taiwan;(2) Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli County, Taiwan;(3) Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan;(4) Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan |
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| Abstract: | Background Numerous proteins can be converted to amyloid-like fibrils to increase cytotoxicity and induce apoptosis, but the methods
generally require a high concentration of protein, vigorous shaking, or fibril seed. As well, the detailed mechanism of the
cytotoxic effects is not well characterized. In this study, we have developed a novel process to convert native proteins into
the fibrillar form. We used globular bovine serum albumin (BSA) as a model protein to verify the properties of the fibrillar
protein, investigated its cellular effects and studied the signaling cascade induced by the fibrillar protein. |
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