|
|||||
|
|
SAR of a novel 'Anthranilamide Like' series of VEGFR-2, multi protein kinase inhibitors for the treatment of cancer |
|
| Authors: | Wickens Philip Kluender Harold Dixon Julie Brennan Catherine Achebe Furahi Bacchiocchi Antonella Bankston Don Bierer Donald Brands Michael Braun Debbie Brown Melissa S Chuang Chih-Yuan Dumas Jacques Enyedy Istvan Hofilena Gloria Hong Zhenqiu Housley Tim Jones Benjamin Khire Uday Kreiman Charles Kumarasinghe Ellalahewage Lowinger Timothy Ott-Morgan Ronda Perkins Louise Phillips Barton Schoenleber Robert Scott William J Sheeler Ryan Redman Anikó Sun Xiuying Taylor Ian Wang Lei Wilhelm Scott Zhang Xiaomei Zhang Mingbao Sullivan Elizabeth Carter Christopher Miglarese Mark Levy Joan |
| Affiliation: | Department of Chemistry Research, Bayer Research Center, 400 Morgan Lane, West Haven, CT 06516, USA. pcwickens@hotmail.com |
| Abstract: | Novel anthranilamides were surprisingly found to exert additional activity on B-RAF. Corresponding thiophene, pyrazole, and thiazole core analogs were prepared as VEGFR-2 inhibitors with c-KIT, and B-RAF activity. Compounds in the phenyl, thiophene, and thiazole series are in vivo active. |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |