Docosahexaenoic acid in red blood cells of women of reproductive age is positively associated with oral contraceptive use and physical activity |
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| Authors: | Anna R Magnusardottir Laufey Steingrimsdottir Holmfridur Thorgeirsdottir Geir Gunnlaugsson Gudrun V Skuladottir |
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| Institution: | 1. Department of Physiology, Faculty of Medicine, University of Iceland, Vatnsmyrarvegi 16, IS-101 Reykjavík, Iceland;2. Public Health Institute of Iceland, Iceland;3. Center for Child Health Services, Primary Health Care Organisation of Reykjavík Area, Reykjavík, Iceland;1. Department of Medicine & Therapeutics, the Chinese University of Hong Kong, Shatin, Hong Kong;2. Department of Chemical Pathology, the Chinese University of Hong Kong, Shatin, Hong Kong;3. Jockey Club Centre for Osteoporosis Care and Control, the Chinese University of Hong Kong, Shatin, Hong Kong;1. Institut National de la Santé Et de la Recherche Médicale U1219, Bordeaux Population Health Research Center, Bordeaux, France;2. Bordeaux University, Institut de Santé Publique, d''Epidémiologie et de Développement, Bordeaux, France;3. Bordeaux University EA 7440, Cultures et Diffusion des Savoirs (CeDS), Bordeaux, France;1. Division of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South Korea;2. Department of Pathology, Dongguk University College of Medicine, Dongguk University Ilsan Hospital, Goyang, South Korea;3. Department of Medicine, Graduate School of Yonsei University, South Korea;4. Division of Pulmonology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea;5. Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Seoul, South Korea;6. Department of Biostatistics, Yonsei University College of Medicine, Seoul, South Korea;7. Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea;1. Department of Cardiology, Hospital Clínico Universitario, Valencia, School of Medicine, University of Valencia, Valencia, Spain;2. Nursing School, University of Valencia, Valencia, Spain;3. Department of Clinical Biochemistry, Hospital Clínico Universitario, Valencia, Spain;4. Department of Physiology, University of Valencia, Valencia, Spain;1. Center for Education and Research on Aging, Concord Hospital, University of Sydney, Sydney, New South Wales, Australia;2. School of Public Health, University of Sydney, Sydney, New South Wales, Australia;3. The Australian Research Council Center of Excellence in Population Aging Research, University of Sydney, Sydney, New South Wales, Australia;4. Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia;5. Australian and New Zealand Army Corps (ANZAC) Research Institute and Charles Perkins Center, University of Sydney, Sydney, New South Wales, Australia;1. Department of Food and Nutrition, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea;2. Research Institute of Human Ecology, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea;3. Department of Food and Nutrition, Daejeon University, 62 Daehak-ro, Dong-gu, Daejeon 300-716, Republic of Korea |
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| Abstract: | Optimal intake of the long-chain n-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA) and proper balance between intake of n-6 PUFA and n-3 PUFA are important for human health. Considerable evidence exists to show that DHA has a marked benefit during pregnancy. Lifestyle factors can affect the biosynthesis of DHA from dietary precursors, incorporation into membranes and degradation. The purpose of this study was to investigate the PUFA composition of red blood cells (RBCs) from women (n=40) in reproductive age, and how it is affected by diet and other lifestyle factors. Of all the lifestyle factors tested oral contraceptive use and physical activity were the ones correlated with DHA in RBCs, after adjustment for DHA intake. The findings indicate that oral contraceptive use and physical activity have a positive impact on the DHA status, as assessed by RBC level, of women in reproductive age. |
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