Rhodomyrtone: A new candidate as natural antibacterial drug from Rhodomyrtus tomentosa |
| |
Authors: | Surasak Limsuwan Erik N Trip Thijs RHM Kouwen Sjouke Piersma Asadhawut Hiranrat Wilawan Mahabusarakam Supayang P Voravuthikunchai Jan Maarten van Dijl Oliver Kayser |
| |
Institution: | 1. Department of Pharmaceutical Biology, University of Groningen, Antonius Deusinglaan 1, NL-9713 AV Groningen, the Netherlands;2. Department of Microbiology and Natural Products Research Center, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand;3. Department of Medical Microbiology, University Medical Center Groningen (UMCG) and University of Groningen, Hanzeplein 1, 9700 RB Groningen, the Netherlands;4. Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand;5. Natural Products Research Center, Faculty of Science, Prince of Songkla University, Songkhla 90112, Thailand |
| |
Abstract: | Rhodomyrtone 6,8-dihydroxy-2,2,4,4-tetramethyl-7-(3-methyl-1-oxobutyl)-9-(2-methylpropyl)-4,9-dihydro-1H-xanthene-1,3(2H)-di-one] from Rhodomyrtus tomentosa (Aiton) Hassk. displayed significant antibacterial activities against Gram-positive bacteria including Bacillus cereus, Bacillus subtilis, Enterococcus faecalis, Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), Staphylococcus epidermidis, Streptococcus gordonii, Streptococcus mutans, Streptococcus pneumoniae, Streptococcus pyogenes, and Streptococcus salivarius. Especially noteworthy was the activity against MRSA with a minimum inhibitory concentration (MIC) and a minimum bactericidal concentration (MBC) ranging from 0.39 to 0.78 μg/ml. As shown for S. pyogenes, no surviving cells were detected within 5 and 6 h after treatment with the compound at 8MBC and 4MBC concentrations, respectively. Rhodomyrtone displays no bacteriolytic activity, as determined by measurement of the optical density at 620 nm. A rhodomyrtone killing test with S. mutans using phase contrast microscopy showed that this compound caused a few morphological changes as the treated cells were slightly changed in color and bigger than the control when they were killed. Taken together, the results support the view that rhodomyrtone has a strong bactericidal activity on Gram-positive bacteria, including major pathogens. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|