Plasma fatty acid profiles in autism: A case-control study |
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| Authors: | MM Wiest JB German DJ Harvey SM Watkins I Hertz-Picciotto |
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| Institution: | 2. Department of Nutrition and Bromatology, University of Granada, Campus de Cartuja, CP 18071 Granada, Spain;3. Departament of Physical and Sports Education, University of Granada, Crta. de Alfacar s/n, CP 18071 Granada, Spain;1. Department of Biochemistry, Bharathi Women''s College (Autonomous), Affiliated to University of Madras, Chennai, Tamil Nadu, India;2. Institute of Social Pediatrics, Government Stanley Medical College and Hospital, Chennai, Tamil Nadu, India;1. Research Institute of Pervasive Developmental Disorders, Ashiya University, 13-22 Rokurokusocho, Ashiya 659-8511, Hyogo, Japan;2. Department of Pediatrics, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu 321-0293, Tochigi, Japan;3. Department of Drug Evaluation and Informatics, School of Pharmaceutical Science, University of Shizuoka., 52-1 Yada, Shizuoka 422-8526, Japan |
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| Abstract: | Increasing evidence is mounting in support of fatty acid metabolism playing a role in neurodevelopmental disorders such as autism. In order to definitely determine whether fatty acid concentrations were associated with autism, we quantitatively measured 30 fatty acids from seven lipid classes in plasma from a large subset of subjects enrolled in the Childhood Autism Risk from Genetics and the Environment (CHARGE) study. The CHARGE study is a large, population-based case-control study on children aged 2–5 born in California. Our subset consisted of 153 children with autism and 97 developmentally normal controls. Results showed that docosahexaenoic acid (DHA, 22:6n-3) was significantly decreased in phosphatidylethanolamine. Dimethyl acetals were significantly decreased in phosphatidylethanolamine and phosphatidylcholine as well. These results are consistent with the only other study to measure dimethyl acetals in children with autism, and suggest that the function of peroxisomes and the enzymes of the peroxisome involved with fatty acid metabolism may be affected in autism. |
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