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Antitrypanosomal activity of some pregnane glycosides isolated from Caralluma species |
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| Authors: | Essam Abdel-Sattar Naglaa G Shehab Chikara Ichino Hiroaki Kiyohara Aki Ishiyama Kazuhiko Otoguro Satoshi Omura Haruki Yamada |
| Institution: | 1. Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia;2. Department of Pharmacognosy, Faculty of Pharmacy, Cairo university, Cairo 11562, Egypt;3. Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan;4. Research Centre for Tropical Diseases, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan |
| Abstract: | Pregnane glycosides previously isolated from genus Caralluma (C. Penicillata, C. tuberculata and C. russelliana) were tested for their antitrypanosomal activity. Penicilloside E showed the highest antitrypanosomal activity (IC50 1.01 μg/ml) followed by caratuberside C (IC50 1.85 μg/ml), which exhibited the highest selectivity index (SI 12.04). It was noticed that acylation is required for the antitrypanosomal activity while glycosylation at C-20 has no significant effect on the activity. |
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