Vasorelaxant effects of forsythide isolated from the leaves of Forsythia viridissima on NE-induced aortal contraction |
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| Authors: | T Iizuka H Sakai H Moriyama N Suto M Nagai D Bagchi |
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| Institution: | 1. Laboratory of Pharmacognosy, Yokohama College of Pharmacy, Matano-cho 601, Tozuka-ku, Yokohama, Kanagawa 245-0066, Japan;2. Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan;3. Laboratory of Pharmcotherapeutics, Showa Pharmaceutical University, 3-3165 Higashi-tamagawagakuen, Machida, Tokyo 194-8543, Japan;4. Ohu University School of Pharmaceutical Sciences, Misumido 31-1, Tomita-machi, Koriyama 963-8611, Japan;5. Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, TX, USA |
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| Abstract: | Forsythide (F1) isolated from the leaves of Forsythia viridissima (Oleaceae) showed vasorelaxant effects on norepinephrine (NE)-induced contraction of rat aorta with or without endothelium. This compound did not affect contraction induced by high concentration potassium (60 mM K+) and phorbol 12,13-diacetate, but inhibited NE-induced contraction in the presence of nicardipine. These results demonstrated the inhibitory effects of F1 on NE-induced vasocontraction presumably due to decrease of calcium influx from extracellular area, which was induced by NE. |
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