| 中国汉族人群2型糖尿病易感性相关基因多态性 |
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| 引用本文： | 徐佳岱[综述],;韩晓[审阅].中国汉族人群2型糖尿病易感性相关基因多态性[J].国外医学：分子生物学分册,2009(6):550-554. |
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| 作者姓名： | 徐佳岱[综述] ;韩晓[审阅] |
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| 作者单位： | 南京医科大学生物化学与分子生物学系,南京市210029 |
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| 摘 要： | 2型糖尿病（type2 diabetes mellitus，T2DM）的发病与多个基因累加效应及多种环境因素相关。已在中国汉族人群中研究过的与T2DM易感性相关的基因多态性包括：全基因组相关研究中的CDKAL1、CDKN2A／B、SLC30A8、IGF2BP2、HHEX、FTO以及KCNQI基因；脂联素基因；核呼吸因子基因；葡萄糖激酶基因；肿瘤坏死因子α基因等。探索这些易感基因可以为人类治疗T2DM起到极大的推动作用。但至今已明确的基因依然很少，国内外的研究结果不尽相同，尚需进一步地深入研究。
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| 关 键 词： | 基因多态性 2型糖尿病 中国人群 |
Single-Nucleotide Polymorphisms of Candidate Genes for Type 2 Diabetes in Chinese Han Population |
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| Institution: | XU Jiadai, HAN Xiao (Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, 210029, China) |
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| Abstract: | Type 2 diabetes mellitus （T2DM） is determined by multiple gene additive effects and various environmental factors. The single-nucleotide polymorphisms （SNPs） related to T2DM candidate genes in the examined Chinese population include the genome-wide associated CDKAL1, CDKN2A/B, SLC30A8, IGF2BP2, HHEX, FTO and KCNQ1 genes, the adiponectin gene, the nuclear respiratory factor 1 gene, the glucokinase gene, and the tumor necrosis factor gene, etc. It is of great importance of exploring these susceptible genes to understand T2DM pathogenesis and im- prove T2DM treatment. However, few genes have been determined, due to divisive results. There- fore, further investigation needs to be undertaken. |
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| Keywords: | single-nucleotide polymorphisms （SNPs） type 2 diabetes mellitus （ T2DM ） Chinese population |
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