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5-Hydroxytryptamine stimulates Rb efflux from pancreatic β-cells
Authors:Per Lindstr  m,Janove Sehlin
Affiliation:Per Lindström,Janove Sehlin
Abstract:The effects of 5-hydroxytryptamine and 5-hydroxytryptophan on 86Rb+ efflux from prelabelled ob/ob-mouse islets were studied to better understand the cellular mechanisms underlying the effects of 5-hydroxytryptamine and 5-hydroxytryptophan on insulin release. 5-Hydroxytryptophan (4 mM) had no effect on 86Rb+ efflux either at a low (3 mM) or at a high (20 mM) d-glucose concentration, whereas 5-hydroxytryptamine (4 mM) stimulated 86Rb+ efflux at both glucose concentrations. These results indicate that 5-hydroxytryptamine may reduce glucose-induced insulin release by inhibiting early steps in the β-cell stimulus-secretion coupling.
Keywords:Pancreatic islet   5-Hydroxytryptamine   5-Hydroxytryptophan   86Rb+ efflux
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