Role of the environment in the interaction of nonintercalators with Z-DNA |
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| Authors: | K E Rao N Ramesh D Choudhury S K Brahmachari V Sasisekharan |
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| Institution: | Molecular Biophysics Unit, Indian Institute of Science, Bangalore. |
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| Abstract: | Interaction of the DNA binding nonintercalators Netropsin, Distamycin and the mPD derivative with Z-DNA has been studied. It has been found that environmental factors like the solvent and added cations significantly modulate the interaction of these ligands with Z-DNA. However no definite Z to B transition in presence of these ligands was found in any case, in contrast to previously reported results (Ch. Zimmer, C. Marck and W. Guschlbauer, FEBS Lett. 154, 156-160 (1983)). |
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