The role of antibody in cellular cytotoxicity to culture human colon carcinoma cells. |
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| Authors: | L K Trejdosiewicz A J Trejdosiewicz P W Dykes |
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| Institution: | 1. The Department of Immunology, University of Birmingham Medical School, Vincent Drive, Birmingham B15 2TJ, England;2. The General Hospital, Steelhouse Lane, Birmingham B4 6NH, England |
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| Abstract: | The effect of autologous serum in cellular cytotoxicity was compared with the level of antibody towards the same target cells. In cancer patients, a highly significant correlation (P < 0.001) argues that enhancement of cytotoxicity by autologous serum is due to high antibody levels, and conversely an inhibition of cytotoxicity is associated with low antibody. Moreover, some antibody was detected in virtually all cancer patient and normal donor sera. It is suggested that antibody may be responsible for cytotoxicity conventionally ascribed to “natural killer” cells. |
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