Implications of Pericardial,Visceral and Subcutaneous Adipose Tissue on Vascular Inflammation Measured Using 18FDG-PET/CT |
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Authors: | Ho Cheol Hong Soon Young Hwang Soyeon Park Ja Young Ryu Hae Yoon Choi Hye Jin Yoo Ji-A Seo Sin Gon Kim Nan Hee Kim Sei Hyun Baik Dong Seop Choi Sungeun Kim Kyung Mook Choi |
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Affiliation: | 1. Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea.; 2. Department of Biostatistics, College of Medicine, Korea University, Seoul, Korea.; 3. Department of Nuclear Medicine, College of Medicine, Korea University, Seoul, Korea.; IRCCS Scientific Institute and Regional General Hospital Casa Sollievo della Sofferenza Opera di Padre Pio da Pietrelcina, ITALY, |
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Abstract: | ObjectivePericardial adipose tissue (PAT) is associated with adverse cardiometabolic risk factors and cardiovascular disease (CVD). However, the relative implications of PAT, abdominal visceral and subcutaneous adipose tissue on vascular inflammation have not been explored.Method and ResultsWe compared the association of PAT, abdominal visceral fat area (VFA), and subcutaneous fat area (SFA) with vascular inflammation, represented as the target-to-background ratio (TBR), the blood-normalized standardized uptake value measured using 18F-Fluorodeoxyglucose Positron Emission Tomography (18FDG-PET) in 93 men and women without diabetes or CVD. Age- and sex-adjusted correlation analysis showed that PAT, VFA, and SFA were positively associated with most cardiometabolic risk factors, including systolic blood pressure, LDL-cholesterol, triglycerides, glucose, insulin resistance and high sensitive C-reactive proteins (hsCRP), whereas they were negatively associated with HDL-cholesterol. In particular, the maximum TBR (maxTBR) values were positively correlated with PAT and VFA (r = 0.48 and r = 0.45, respectively; both P <0.001), whereas SFA showed a relatively weak positive relationship with maxTBR level (r = 0.31, P = 0.003).ConclusionThis study demonstrated that both PAT and VFA are significantly and similarly associated with vascular inflammation and various cardiometabolic risk profiles. |
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