Integrated analyses of copy number variations and gene differential expression in lung squamous-cell carcinoma |
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| Authors: | Zhao Yang Bing Zhuan Ying Yan Simin Jiang Tao Wang |
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| Institution: | .Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030 China ;.Department of Respiratory and Critical Care Medicine, Ningxia People’s Hospital, Yinchuan, 750011 China |
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| Abstract: | BackgroundAlthough numerous efforts have been made, the pathogenesis underlying lung squamous-cell carcinoma (SCC) remains unclear. This study aimed to identify the CNV-driven genes by an integrated analysis of both the gene differential expression and copy number variation (CNV).ResultsA higher burden of the CNVs was found in 10–50 kb length. The 16 CNV-driven genes mainly located in chr 1 and chr 3 were enriched in immune response e.g. complement factor H (CFH) and Fc fragment of IgG, low affinity IIIa, receptor (FCGR3A)], starch and sucrose metabolism e.g. amylase alpha 2A (AMY2A)]. Furthermore, 38 TFs were screened for the 9 CNV-driven genes and then the regulatory network was constructed, in which the GATA-binding factor 1, 2, and 3 (GATA1, GATA2, GATA3) jointly regulated the expression of TP63.ConclusionsThe above CNV-driven genes might be potential contributors to the development of lung SCC. |
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| Keywords: | Lung squamous-cell carcinoma Differentially expressed genes Copy number variation Copy number variation-driven genes |
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