Artificial Loading of ASC Specks with Cytosolic Antigens |
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| Authors: | Ali Can Sahillio?lu Nesrin ?z?ren |
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| Affiliation: | 1. Apoptosis and Cancer Immunology Laboratory (AKiL), Department of Molecular Biology and Genetics, Bogazici University, Istanbul, Turkey.; 2. Life Sciences and Technologies Research Center, Bogazici University, Istanbul, Turkey.; University of the Pacific, UNITED STATES, |
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| Abstract: | Inflammasome complexes form upon interaction of Nod Like Receptor (NLR) proteins with pathogen associated molecular patterns (PAPMS) inside the cytosol. Stimulation of a subset of inflammasome receptors including NLRP3, NLRC4 and AIM2 triggers formation of the micrometer-sized spherical supramolecular complex called the ASC speck. The ASC speck is thought to be the platform of inflammasome activity, but the reason why a supramolecular complex is preferred against oligomeric platforms remains elusive. We observed that a set of cytosolic proteins, including the model antigen ovalbumin, tend to co-aggregate on the ASC speck. We suggest that co-aggregation of antigenic proteins on the ASC speck during intracellular infection might be instrumental in antigen presentation. |
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