Anti-Osteoarthritic Effects of the Litsea japonica Fruit in a Rat Model of Osteoarthritis Induced by Monosodium Iodoacetate |
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Authors: | Yong Joon Jeong Inhye Kim Joon Hyung Cho Dae Won Park Jung Eun Kwon Moon Won Jung Xue Meng Se Min Jo Hae Seong Song Young Mi Cho Sang Mok Song Young-Min Ham Yong-Hwan Jung Chang Sook Kim Weon-Jong Yoon Se Chan Kang |
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Institution: | 1. Department of Life Science, Gachon University, Seongnam, Republic of Korea.; 2. Department of Food and Nutrition, Hanyang University, Seoul, Republic of Korea.; 3. Department of Biological & Environmental Science, Dongguk University, Seoul, Republic of Korea.; 4. Jeju Biodiversity Research Institute, Jeju Technopark, Jeju, Republic of Korea.; National Center for Scientific Research Demokritos, GREECE, |
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Abstract: | Osteoarthritis (OA) is a degenerative chronic disease that affects various tissues surrounding the joints, such as the subchondral bone and articular cartilage. The onset of OA is associated with uncontrolled catabolic and anabolic remodeling processes of the joints, including the cartilage and subchondral bone, to adapt to local biological and biochemical signals. In this study, we determined whether 70% ethanolic (EtOH) extract of Litsea japonica fruit (LJFE) had beneficial effects on the articular cartilage, including structural changes in the tibial subchondral bone, matrix degradation, and inflammatory responses, in OA by using a rat model of monosodium iodoacetate-induced OA. Our results showed that administration of LJFE increased the bone volume and cross-section thickness, but the mean number of objects per slice in this group was lower than that in the OA control (OAC) group. In addition, the LJFE decreased the expression of inflammatory cytokines. Compared to the OAC group, the group treated with high doses of LJFE (100 and 200 mg/kg) showed a more than 80% inhibition of the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases. Our results suggest that LJFE can be used as a potential anti-osteoarthritic agent. |
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