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Discovery of a non‐stereoselective cytochrome P450 catalyzing either 8α‐ or 8β‐hydroxylation of germacrene A acid from the Chinese medicinal plant,Inula hupehensis
Authors:Junbo Gou  Fuhua Hao  Chongyang Huang  Moonhyuk Kwon  Fangfang Chen  Changfu Li  Chaoyang Liu  Dae‐Kyun Ro  Huiru Tang  Yansheng Zhang
Affiliation:1. CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, China;2. University of Chinese Academy of Sciences, Beijing, China;3. Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Centre for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematis, University of Chinese Academy of Sciences, Wuhan, China;4. Department of Biological Sciences, University of Calgary, Calgary, Canada;5. State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai, China
Abstract:
Keywords:C12  8‐fused STLs  cytochrome P450 (CYP)  germacrene A acid C8‐hydroxylase     Inula hupehensis     inunolide  sesquiterpene lactones (STLs)
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