光镊和拉曼光镊在生物医学研究中的应用

光镊是由美国科学家Arthur Ashkin于1986年发明的,是一种利用高度汇聚的激光束产生的三维梯度势阱来俘获、操纵微小粒子的技术。因其可俘获、操纵单个细胞,并在细胞和亚细胞层次上为生物医学研究提供方便,近年来,已越来越多地被应用于生物医学研究中。本文在介绍光镊的原理和特点的基础上,阐述了光镊(尤其是拉曼光镊)技术在生物医学领域中的研究进展、现状和展望。

Application of Optical Tweezers and Raman Tweezers in the Biomedical Research

Optical tweezers developed by Arthur Ashkin in 1986 are the technology in which a highly focalized beam of laser is utilized to form a three-dimensional gradient force trap to capture and manipulate particles in the micron-sized regime.Recently,optical tweezers have been increasingly used in the realm of biomedical research,because it can capture and manipulate single cell and facilitate the biomedical research in the cellular and sub-cellular level.In this review,the principles and characters of optical tweezers are introduced.Next,this article also presents the biomedical research progress facilitated by the technology of optical tweezers and Raman tweezers.