Structure activity studies of a novel cytotoxic benzodiazepine |
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| Authors: | Boitano Anthony Emal Cory D Leonetti Francesco Blatt Neal B Dineen Thomas A Ellman Jonathan A Roush William R Opipari Anthony W Glick Gary D |
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| Institution: | Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, MI 48109-1055, USA. |
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| Abstract: | Analogues of Bz-423, a pro-apoptotic 1,4-benzodiazepine with potent activity in animal models of systemic lupus erythematosus and rheumatoid arthritis, have been designed, synthesized, and evaluated in cell-culture assays. The results of these experiments have defined the structural elements of this new cytotoxic agent required for activity. |
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