Conservation of pregnancy-specific glycoprotein (PSG) N domains following independent expansions of the gene families in rodents and primates期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Conservation of pregnancy-specific glycoprotein (PSG) N domains following independent expansions of the gene families in rodents and primates

Authors:	Andrew?S?McLellan,Wolfgang?Zimmermann,Tom?Moore author-information" > author-information__contact u-icon-before" > mailto:t.moore@ucc.ie" title=" t.moore@ucc.ie" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) Department of Biochemistry, Biosciences Institute, University College Cork, College Road, Cork, Ireland;(2) Tumor Immunology Group, LIFE Center, University Clinic Grosshadern, Ludwig-Maximilians-University Muenchen, Marchioninistrasse 23, D-81377 Muenchen, Germany

Abstract:	Background Rodent and primate pregnancy-specific glycoprotein (PSG) gene families have expanded independently from a common ancestor and are expressed virtually exclusively in placental trophoblasts. However, within each species, it is unknown whether multiple paralogs have been selected for diversification of function, or for increased dosage of monofunctional PSG. We analysed the evolution of the mouse PSG sequences, and compared them to rat, human and baboon PSGs to attempt to understand the evolution of this complex gene family.

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