Comparative mapping of sequence-based and structure-based protein domains期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Comparative mapping of sequence-based and structure-based protein domains

Authors:	Ya?Zhang author-information" > author-information__contact u-icon-before" > mailto:yzz@psu.edu" title=" yzz@psu.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,John-Marc?Chandonia,Chris?Ding,Stephen?R?Holbrook author-information" > author-information__contact u-icon-before" > mailto:srholbrook@lbl.gov" title=" srholbrook@lbl.gov" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA;(2) Computational Research Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA;(3) School of Information Sciences and Technology, The Pennsylvania State University, University Park, PA 16802, USA

Abstract:	Background Protein domains have long been an ill-defined concept in biology. They are generally described as autonomous folding units with evolutionary and functional independence. Both structure-based and sequence-based domain definitions have been widely used. But whether these types of models alone can capture all essential features of domains is still an open question.

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