Regulation of the immune system by synthetic polynucleotides. VII. Suppression induced by pretreatment with poly A:U. |
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Authors: | C K Morris A G Johnson |
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Affiliation: | Department of Microbiology, The University of Michigan, Ann Arbor, Michigan 48109 USA |
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Abstract: | Pretreatment of mouse spleen cells with polyadenylic-polyuridylic acid complexes (poly A:U) either in vivo or in vitro 24 hr prior to addition of antigen, resulted in a substantial time dependent decrease in anti-SRBC PFC. Enhancement was observed 6 hr after poly A:U, while inhibition did not become evident until 24 hr after pretreatment. Inhibition of the PFC response appeared to result from poly A:U activation of a nylon wool adherent, T suppressor cell, capable of diminishing the response of normal spleen cells exposed to antigen on co-culture. |
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