Death and proliferation of chondrocytes in the degraded mandibular condylar cartilage of rats induced by experimentally created disordered occlusion |
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Authors: | Kai Jiao Mei-Qing Wang Li-Na Niu Juan Dai Shi-Bin Yu Xiao-Dong Liu Guo-Wei Wang |
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Institution: | (1) Department of Oral Anatomy and Physiology and TMD, School of Stomatology, Fourth Military Medical University, 710032 Xi’an, China;(2) Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, 710032 Xi’an, China;(3) Department of Orthodontics, School of Stomatology, Fourth Military Medical University, 710032 Xi’an, China |
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Abstract: | Objective To investigate the effect of experimentally created disordered occlusion (ECDO) on cell death and proliferation in rat mandibular
condylar cartilage.
Methods Sprague–Dawley rats were randomly assigned to experimental and control groups. In the experimental groups, ECDO was created
by the dental orthodontic method. By means of histological evaluation, immunohistochemistry and TUNEL staining, we studied
the histomorphological changes, the death and proliferation of chondrocytes.
Results Time- and sex-related progressive histologic degradation was observed in the condylar cartilage of ECDO rats, accompanied
with diminished chondrocyte proliferation in the female 12-week ECDO subgroup (P < 0.05). An increase in the number of apoptotic chondrocytes was seen in both the female 8- and 12-week ECDO subgroups and
in the male ECDO 12-week subgroup (all P < 0.05), but not in the male ECDO 8-week subgroup (P > 0.05).
Conclusion ECDO induces degradation in the rat condylar cartilage accompanied by an increase in chondrocyte death. |
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Keywords: | Apoptosis Proliferation Temporomandibular joint (TMJ) Osteoarthritis (OA) Cartilage Sex difference |
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