Regulation of the functional and mechanical properties of platelet and red blood cells by nitric oxide donors |
| |
| Authors: | E V Shamova O D Bichan E S Drozd I V Gorudko S A Chizhik K B Shumaev S N Cherenkevich A F Vanin |
| |
| Institution: | (1) School of Engineering, University of Vermont, Burlington, VT 05405, USA;(2) Department of Mechanical Engineering, The University of Texas at San Antonio, San Antonio, TX, USA;(3) Department of Mechanical and Industrial Engineering, 2408 Seamans Center, College of Engineering, The University of Iowa, Iowa City, IA 52242, USA |
| |
| Abstract: | The effect of NO donors (sodium nitroprusside, S-nitrosoglutathione, dinitrosyl-iron complexes) on the functional and mechanical
properties of human platelets and red blood cells has been investigated. It has been established by atomic force microscopy
that NO donor-induced platelet disaggregation is accompanied by changes in the elastic properties of cells. It has been shown
that, in the presence of NO donors, the detergent-induced hemolysis of red blood cells is delayed, and the elasticity modulus
of these cells decreases. The results obtained indicate that NO donors regulate the structural and functional properties of
platelets and red blood cells. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
