5S rRNA and ribosome |
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Authors: | G M Gongadze |
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Institution: | Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, Russia. gongadze@vega.protres.ru |
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Abstract: | 5S rRNA is an integral component of the ribosome of all living organisms. It is known that the ribosome without 5S rRNA is
functionally inactive. However, the question about the specific role of this RNA in functioning of the translation apparatus
is still open. This review presents a brief history of the discovery of 5S rRNA and studies of its origin and localization
in the ribosome. The previously expressed hypotheses about the role of this RNA in the functioning of the ribosome are discussed
considering the unique location of 5S rRNA in the ribosome and its intermolecular contacts. Based on analysis of the current
data on ribosome structure and its functional complexes, the role of 5S rRNA as an intermediary between ribosome functional
domains is discussed. |
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Keywords: | |
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