Atomic force microscopy of animal cells: Advances and prospects |
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Authors: | Yu M Efremov D V Bagrov E V Dubrovin K V Shaitan I V Yaminskii |
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Institution: | 1.Biological Faculty,Moscow State University,Moscow,Russia;2.Physical Faculty,Moscow State University,Moscow,Russia |
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Abstract: | We review the advances of the method of atomic force microscopy (AFM) for investigating the animal cells and analyze its development,
paying much attention to studies of living cells. We consider the specific features and tasks of AFM, and a number of special
AFM-based techniques. We discuss the choice of probe geometry for studies of animal cells, determination of cell adhesion
on substrate, mapping of the cell surface using chemically modified cantilevers, and analysis of the distribution of molecular
components inside the cell with the use of micro- and nanosurgical approaches, as well as combining AFM with optical and laser
scanning confocal microscopy, and the possible applications of AFM in biotechnology and medicine. |
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