18-Substituted steroids. Part 15. 6 beta-Hydroxylation of aldosterone by liver |
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| Authors: | D N Kirk P J Burke H C Toms S A Latif D J Morris |
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| Affiliation: | Department of Chemistry, Queen Mary College, London, UK. |
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| Abstract: | 6 beta-Hydroxyaldosterone and 6 beta-hydroxy-17-isoaldosterone, characterized by high-field NMR studies, are among the major polar metabolites formed from aldosterone by incubation with rat liver slices or microsomal fraction. It is uncertain at present whether the 17-iso product results from an enzymatic or a chemical inversion of configuration. Periodate degradation of the 6 beta-hydroxyaldosterone gave 6 beta-hydroxyaldosterone gamma-lactone, identical with a synthetic sample. |
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