Attenuation of oxidative stress and cardiac dysfunction by bisoprolol in an animal model of dilated cardiomyopathy |
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Authors: | Ichihara Sahoko Yamada Yoshiji Ichihara Gaku Kanazawa Hiroaki Hashimoto Katsunori Kato Yosuke Matsushita Aya Oikawa Shinji Yokota Mitsuhiro Iwase Mitsunori |
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Affiliation: | Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Japan. saho@gene.mie-u.ac.jp |
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Abstract: | Oxidative stress is an important susceptibility factor for dilated cardiomyopathy. We have investigated the effects of bisoprolol, a beta1-selective adrenoceptor blocker, on oxidative stress and the development of cardiac dysfunction in a model of dilated cardiomyopathy. Male TO-2 and control hamsters at 8 weeks of age were treated with bisoprolol (5 mg/kg per day) or vehicle for 4 weeks. Treatment with bisoprolol prevented the progression of cardiac dysfunction in TO-2 hamsters. This drug did not affect the increase in NADPH oxidase activity but prevented the reduction in activity and expression of mitochondrial manganese-dependent superoxide dismutase as well as the increases in the concentrations of interleukin-1beta and tumor necrosis factor-alpha in the left ventricle of TO-2 hamsters. Attenuation of the development of cardiac dysfunction by bisoprolol may thus result in part from normalization of the associated increases in the levels of oxidative stress and pro-inflammatory cytokines in the left ventricle. |
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Keywords: | Adrenoceptors Cardiomyopathy Cytokines Heart failure NADPH oxidase |
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