Autoantibodies to nucleolin cross-react with histone H1 in systemic Lupus erythematosus |
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| Authors: | Wael N. Jarjour Seiji Minota Robert A. S. Roubey Toshihide Mimura John B. Winfield |
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| Affiliation: | (1) Thurston Arthritis Research Center, The University of North Carolina, 27599-7280 Chapel Hill, NC, USA;(2) the Division of Rheumatology and Immunology, The University of North Carolina, 27599-7280 Chapel Hill, NC, USA;(3) Present address: 3rd Department of Internal Medicine, University of Tokyo, Tokyo, Japan |
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| Abstract: | IgM autoantibodies to nucleolin and histone H1 are strongly associated in the serum of patients with systemic lupus erythematosus. IgM eluted from immobilized nucleolin specifically stained histone H1 blotted to nitrocellulose; conversely, IgM eluates prepared from immobilized histone H1 stained nucleolin blots. We conclude that the linkage of anti-nucleolin and anti-histone H1 autoantibodies in SLE is due, at least in part, to immunologic cross-reactivity between these two autoantigens, which share certain similar structural features.Abbreviation SLE Systemic Lupus erythematosus |
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| Keywords: | systemic Lupus erythematosus autoantibody IgM nucleolin histone |
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