Effect of glucagon administration on mice liver fructose-1, 6-bisphosphatase.

Intravenous administration of glucagon in mouse (200 μg/100 gm body wt), stimulated liver fructose-1,6-bisphosphatase at physiological pH by approximately 100% within 15 minutes. The stimulation was not due to protein synthesis. Similar stimulation was also observed on administration of cyclic AMP. Removal of the adrenal gland abolished the stimulatory effect of glucagon but not of cyclic AMP.