Regulation of 5-lipoxygenase enzyme activity |
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| Authors: | Rådmark Olof Samuelsson Bengt |
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| Institution: | Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, S-17177 Stockholm, Sweden. olof.radmark@mbb.ki.se |
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| Abstract: | In this article, regulation of human 5-lipoxygenase enzyme activity is reviewed. First, structural properties and enzyme activities are described. This is followed by the activating factors: Ca2+, membranes, ATP, and lipid hydroperoxide. Also, studies on phosphorylation of 5-lipoxygenase and nuclear localization sequences are reviewed. |
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| Keywords: | Leukotriene Eicosanoid Arachidonic acid |
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