GLYCINE SPECIFIC [3H]STRYCHNINE BINDING IN THE PIGEON CNS |
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Authors: | D. LeFort,,,H. Henke, M. Cué anod |
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Affiliation: | Institute for Brain Research, University of Zurich, Zurich, Switzerland |
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Abstract: | Abstract— Glycine sensitive [3H]strychnine binding has been demonstrated in the pigeon CNS. The kinetic parameters in spinal cord, tectum, telencephalon and cerebellum in this order were: K n, (nM) 5 , 5, 2.3, 6 and B max (fmol/mg protein) 1000, 275, 92, 20. The effect of various amino acids and strychnine analogs on the binding was measured. Retinal ablation caused a 22% decrease in the glycine sensitive [3H]strychnine binding in the tectum while lesions destroying up to 80% of the nucleus Ipc had no effect. |
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