GLYCINE SPECIFIC [3H]STRYCHNINE BINDING IN THE PIGEON CNS

Abstract— Glycine sensitive ³H]strychnine binding has been demonstrated in the pigeon CNS. The kinetic parameters in spinal cord, tectum, telencephalon and cerebellum in this order were: K _n, (nM) 5 , 5, 2.3, 6 and B _max (fmol/mg protein) 1000, 275, 92, 20. The effect of various amino acids and strychnine analogs on the binding was measured. Retinal ablation caused a 22% decrease in the glycine sensitive ³H]strychnine binding in the tectum while lesions destroying up to 80% of the nucleus Ipc had no effect.