首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Therapeutic effects of Typha elephantina leave’s extract against paracetamol induced renal injury in rabbits
Authors:Bashir Ahmad  Ali Muhammad Yousafzai  Ayaz Ali Khan  Mohammad Attaullah  Waqar Ali  Saeed Ahmad  Ghazala Yasmin Zamani  Farhat Naz  Sumayya Raziq  Amjad Ali
Abstract:Present study focuses on ameliorative potential of Typha elephantina leave’s aqueous (TE.AQ) extract against Paracetamol (PCM) induced toxicity in rabbits. We fed the male rabbits with 300 mg PCM in alone and in combination with TE.AQ at different doses i.e. (100, 200 and 300 mg/kg body weight) or silymarin (100 mg/kg) daily for 21 days. PCM in alone significantly (P < 0.5) increased serum urea, uric acid, creatinine, total protein, albumin, globulin and blood urea nitrogen. Serum sodium, potassium and magnesium level were high. The glutathione, radical scavenging activity and Thiobarbituric acid reactive substances were significantly reduced. Treatment with TE.AQ at dose rate 300 mg/kg body weight and Silymarin significantly ameliorated all the parameters when compared with PCM administered group. The 100 and 200 mg of TE.AQ showed no significant effects. The histopathological examination confirmed the therapeutic potential of TE.AQ. These results established the presence of natural antioxidants in Typha elephantina leaves.
Keywords:Typha elephantina  Paracetamol  Aqueous extract  Serum biochemical parameters  Serum electrolytes  Silymarin
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号