Penicillium aurantiogriseum Dierckx 1901: Producer of Diketopiperazine Alkaloids (Roquefortine and 3,12-Dihydroroquefortine), Isolated from Permafrost |
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| Authors: | A G Kozlovsky V P Zhelifonova V M Adanin T V Antipova S M Ozerskaya N E Ivanushkina U Grafe |
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| Institution: | (1) Russian Academy of Sciences, Skryabin Institute of Biochemistry and Physiology of Microorganisms, pr. Nauki 5, Pushchino, Moscow oblast, 142290, Russia;(2) Hans-Knoll Institute of Natural Product Research, Jena, D-07745, Germany |
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| Abstract: | Secondary metabolites of three strains of Penicillium aurantiogriseumisolated from permafrost sediments were identified. It was found that these fungi synthesized the diketopiperazine alkaloids roquefortine and 3,12-dihydroroquefortine. The strain VKM FW-766 synthesized alkaloids in the course of certain growth-related processes. When the strain was grown on a mineral medium, the time courses of the roquefortine and 3,12-dihydroroquefortine concentrations were characterized by biphasic curves. |
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