A novel series of urea-based peptidomimetic calpain inhibitors |
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Authors: | Sanders M Lee Donkor Isaac O |
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Institution: | Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, Memphis, TN 38163, USA. |
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Abstract: | A series of peptide aldehyde derivatives in which the P(2) chiral carbon has been replaced with nitrogen were synthesized as urea-based peptidomimetic inhibitors of mu-calpain. The compounds mirrored the general SAR of peptidyl aldehyde calpain inhibitors but displayed greater selectivity for mu-calpain over cathepsin B. |
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