Polycationic catalysts for phosphodiester bond cleavage on the basis of 1,4-diazabicyclo[2.2.2]octane |
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| Authors: | E A Burakova N A Kovalev I L Kuznetzova M A Zenkova V V Vlassov V N Sil’nikov |
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| Institution: | (1) Novosibirsk Institute of Chemical Biology and Fundamental Medicine, Siberian Division, Russian Academy of Sciences, pr. Akademika Lavrent’eva 8, Novosibirsk, 630090, Russia |
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| Abstract: | A number of tetracationic compounds capable of phosphodiester bond cleavage within a 21-membered ribooligonucleotide were designed and synthesized. The artificial ribonucleases represent two residues of quaternized 1,4-diazabicyclo2.2.2]octane bearing alkyl substituents of various lengths and connected with a rigid linker. The efficiency of cleavage of phosphodiester bonds in an RNA target depends on the linker structure and the length of alkyl substituent. |
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| Keywords: | artificial ribonucleases 1 4-diazabicyclo[2 2 2]octane polycationic molecules |
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