Specific expression of lacZ and cre recombinase in fetal thymic epithelial cells by multiplex gene targeting at the Foxn1 locus |
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| Authors: | Julie Gordon,Shiyun Xiao,Bernard Hughes Suffix" >III,Dong-ming Su,Samuel P Navarre,Brian G Condie,Nancy R Manley |
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| Affiliation: | (1) Department of Genetics, University of Georgia, Athens, GA 30602, USA;(2) Dept. of Biomedical Research, The University of Texas Health Center at Tyler, 11937 US Highway 271, Tyler, TX 75708, USA;(3) Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA |
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| Abstract: | Background Thymic epithelial cells (TECs) promote thymocyte maturation and are required for the early stages of thymocyte development and for positive selection. However, investigation of the mechanisms by which TECs perform these functions has been inhibited by the lack of genetic tools. Since the Foxn1 gene is expressed in all presumptive TECs from the early stages of thymus organogenesis and broadly in the adult thymus, it is an ideal locus for driving gene expression in differentiating and mature TECs. |
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