Rybp,a polycomb complex-associated protein,is required for mouse eye development |
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| Authors: | Melinda K Pirity Wei-Lin Wang Louise V Wolf Ernst R Tamm Nicole Schreiber-Agus Ales Cvekl |
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| Affiliation: | (1) Department of Molecular Genetics, Albert Einstein College of Medicine, 10461 Bronx, NY, USA;(2) Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany;(3) Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, 10461 Bronx, NY, USA |
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| Abstract: | Background Rybp (Ring1 and YY1 binding protein) is a zinc finger protein which interacts with the members of the mammalian polycomb complexes. Previously we have shown that Rybp is critical for early embryogenesis and that haploinsufficiency of Rybp in a subset of embryos causes failure of neural tube closure. Here we investigated the requirement for Rybp in ocular development using four in vivo mouse models which resulted in either the ablation or overexpression of Rybp. |
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