Quantifying the metabolic capabilities of engineered <Emphasis Type="Italic">Zymomonas mobilis</Emphasis> using linear programming analysis |
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Authors: | Ivi C Tsantili M Nazmul Karim Maria I Klapa |
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Institution: | (1) Metabolic Engineering and Systems Biology Laboratory, Institute of Chemical Engineering and High-Temperature Chemical Processes, Foundation for Research and Technology-Hellas, GR-26504 Patras, Greece;(2) Interdepartmental Graduate Program "Mathematical Modelling in Modern Technologies and Finance", National Technical University of Athens, GR-15780 Zografou Campus, Athens, Greece;(3) Department of Chemical Engineering, Texas Tech University, 79409 Lubbock, TX, USA;(4) Department of Chemical and Biomolecular Engineering, University of Maryland, 20742 College Park, MD, USA;(5) Present address: Department of Naval Architecture and Marine Engineering, National Technical University of Athens, GR-15780 Zografou Campus, Athens, Greece |
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Abstract: | Background The need for discovery of alternative, renewable, environmentally friendly energy sources and the development of cost-efficient,
"clean" methods for their conversion into higher fuels becomes imperative. Ethanol, whose significance as fuel has dramatically
increased in the last decade, can be produced from hexoses and pentoses through microbial fermentation. Importantly, plant
biomass, if appropriately and effectively decomposed, is a potential inexpensive and highly renewable source of the hexose
and pentose mixture. Recently, the engineered (to also catabolize pentoses) anaerobic bacterium Zymomonas mobilis has been widely discussed among the most promising microorganisms for the microbial production of ethanol fuel. However,
Z. mobilis genome having been fully sequenced in 2005, there is still a small number of published studies of its in vivo physiology and limited use of the metabolic engineering experimental and computational toolboxes to understand its metabolic
pathway interconnectivity and regulation towards the optimization of its hexose and pentose fermentation into ethanol. |
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