Site-specific acetylation of ISWI by GCN5 |
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| Authors: | Roger Ferreira Anton Eberharter Tiziana Bonaldi Mariacristina Chioda Axel Imhof Peter B Becker |
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| Affiliation: | (1) Adolf-Butenandt-Institut, Molekularbiologie, 80336 Mnchen, Germany;(2) European Patent Office – Biotechnology, D-80339 Mnchen, Germany;(3) Max-Planck Institut fr Biochemie, D-82152 Martinsried, Germany |
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| Abstract: | Background The tight organisation of eukaryotic genomes as chromatin hinders the interaction of many DNA-binding regulators. The local accessibility of DNA is regulated by many chromatin modifying enzymes, among them the nucleosome remodelling factors. These enzymes couple the hydrolysis of ATP to disruption of histone-DNA interactions, which may lead to partial or complete disassembly of nucleosomes or their sliding on DNA. The diversity of nucleosome remodelling factors is reflected by a multitude of ATPase complexes with distinct subunit composition. |
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