Phenotype and distribution of T lymphocytes in Peyer's patches of athymic mice |
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Authors: | Th. H. Ermak R. L. Owen |
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Affiliation: | (1) Cell Biology and Aging Section, VA Medical Center, 4150 Clement Street, 94121 San Francisco, CA, USA;(2) Intestinal Immunology Research Center, University of California, San Francisco, USA |
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Abstract: | Summary The distribution and phenotype of T (Thy-1.2–) cells was examined in Peyer's patches of 8 and 16 week old athymic mice by peroxidase and two-color-fluorescence immunohistochemistry. Despite the generally recognized T cell deficiency of nude mice, some T cells consistently occurred in Peyer's patch domes in all mice. However, many Thy-1.2+ lymphocytes lacked cell surface markers for either helper T cells (L3T4) or cytotoxic/suppressor T cells (Lyt-2), indicating that these cells may be an immature subset of T cells. These cells may represent a population of resident T cell precursors delayed in maturation or T cells newly immigrated to Peyer's patches. |
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