Assessment of brain interactivity in the motor cortex from the concept of functional connectivity and spectral analysis of fMRI data |
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Authors: | S Fall G de Marco |
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Institution: | (1) Laboratoire de Biophysique et Traitement de l’Image Médicale, CHU-nord UPJV Amiens, Amiens Cedex, France |
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Abstract: | Functional magnetic resonance imaging (fMRI) was used to assess the contributions of movement preparation and execution of
a visuomotor task in a cerebral motor network. The functional connectivity of the voxel time series between brain regions
in the frequency space was investigated by performing spectral analysis of fMRI time series. The regional interactivities
between the two portions of the supplementary motor area (pre-SMA and SMA-proper) and the primary motor cortex (M1), defined
as a seed region, were evaluated. The spectral parameter of coherence was used to describe a correlation structure in the
frequency domain between two voxel-based time series and to infer the strength of the functional interaction within our presumed
motor network of connections. The results showed meaningful differences of the functional interactions between the two portions
of the SMA and the M1 area depending on the task conditions. This approach demonstrated the existence of a functional dissociation
between the pre-SMA and SMA-proper subregions. We therefore conclude that spectral analysis is useful for identifying functional
interactions of brain regions and might provide a powerful tool to quantify changes in connectivity profiles associated with
various components of an experimental task. |
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Keywords: | |
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