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Synthesis and pharmacological evaluation of a new class of peroxisome proliferator-activated receptor modulators |
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| Authors: | Thor Markus Beierlein Katarina Dykes Graeme Gustavsson Anna Lena Heidrich Jessica Jendeberg Lena Lindqvist Bengt Pegurier Cecile Roussel Patrick Slater Martin Svensson Stefan Sydow-Bäckman Mona Thornström Ulla Uppenberg Jonas |
| Affiliation: | a Biovitrum AB, Department of Medicinal Chemistry, Rapsgatan 7, Uppsala 751-37, Stockholm, Sweden b Biofocus Plc., Sittingbourne, UK c Pharmacia Corporation, Nerviano, Italy |
| Abstract: | A series of 5-substituted 2-benzoylaminobenzoic acids has been synthesized and assayed for PPAR/γ activity. Both dual activators and selective PPARγ agonists have been identified. This class of compounds was shown to activate the PPARγ receptor through interaction with a novel binding site. |
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