T-cell receptor variable alpha (TCRAV) polymorphisms in European, Chinese, South American, AfroCaribbean, and Gambian populations |
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Authors: | Mark R. Ibberson John P. Copier Elena Llop Cristina Navarrete Adrian V. S. Hill J. Kennedy Cruickshank A. K. L. So |
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Affiliation: | (1) Rheumatology Unit, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road, London W12 ONN, England, GB;(2) Department of Genetics and Cellular Biology, University of Chile, Santiago, Chile, CL;(3) North London Blood Transfusion Centre, Colindale Avenue, London NW9 3BG, England, GB;(4) Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9OU, England, GB;(5) Clinical Epidemiology Unit, Medical School, University of Manchester, Oxford Road, Manchester M13 9PT, England, GB |
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Abstract: | Interactions involving the T-cell receptor (TCR) and major histocompatibility complex (MHC) are fundamental to the generation of a specific immune response. The study of interpopulation differences in TCR genes may identify those genes which are subject to selection, and also provides useful information for future genetic studies in these populations. In this study we present analysis of five TCRAV polymorphisms, for V5S1, V6S1, V8S1, V17S1, and V21S1 loci in five human populations by single-strand conformational polymorphism (SSCP) analysis. Caucasian, Chinese, Gambian, AfroCaribbean, and South American Indians (Mapuches) showed marked interpopulation variation for both the silent (V5S1, V17S1, and V21S1) and coding (V6S1 and V8S1) polymorphisms. In general the alleles were conserved in the different populations, but new, additional variants were found for V5S1 and V17S1 in Gambians and Caucasians. V6S1 overall showed the highest nucleotide diversity, and V6S1 genotype distributions were skewed away from expected values in Chinese and Mapuches. Analysis of allelic associations showed a general lack of linkage disequilibrium between the loci, which was reflected by the absence of strong population-specific haplotypes. Received: 22 April 1997 / Revised: 9 July 1997 |
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Keywords: | T-cell receptor Polymorphism Population |
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