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Quantification of circular DNA breakage by fluorescence scanning of ethidium bromide-stained horizontal gels: application to the effect of intercalating agents |
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| Authors: | C Malvy |
| Institution: | 1. Division of Hematology, Department of Medicine, State University of New York, Stony Brook, New York 11794 USA;2. Division of Hematology-Oncology, Department of Medicine, The New York Hospital-Cornell Medical Center, New York, New York 10021 USA;3. the Specialized Center of Research in Thrombosis, The New York Hospital-Cornell Medical Center, New York, New York 10021 USA |
| Abstract: | Direct scanning of the fluorescence of DNA in ethidium bromide-stained agarose gels allowed the quantification of closed and open circular DNA forms. Fluorescence of form I was higher than expected compared to form II. Application of this technique is shown for an intercalating drug treatment of DNA. |
| Keywords: | protease protease inhibitor Factor X antithrombin immunochemical methods |
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