Histochemical localization of esterase activity in Schistosomes |
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| Authors: | P J Fripp |
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| Affiliation: | 1. School of Mechatronics Engineering, Xi’an Technological University, Xi’an 710021, People''s Republic of China;2. Second b Xi’an KunLun Industrial (Group) Co., Ltd., Xi’an 710043, People''s Republic of China;3. CNGC QIQIHAER NORTH MACHINERY CORPORATION LIMITED, 161000, People''s Republic of China;4. AVIC XI’AN AERO-ENGINE (GROUP) LTD., Xi’an 710021, People''s Republic of China;1. Laboratory of Membrane Biogenesis, UMR 5200 CNRS, University of Bordeaux, 71 avenue Edouard Bourlaux, 33140 Villenave d’Ornon, France;2. Biosciences, CLES, Exeter University, Geoffrey Pope Building, Stocker Rd, Exeter EX4 4QD, UK;3. School of Biological Sciences, University of Bristol, Bristol Life Sciences Building, 24 Tyndall Avenue, Bristol BS8 1TQ, UK;4. Ghent University, Department of Plant Biotechnology and Bioinformatics, 9052 Ghent, Belgium;5. VIB Center for Plant Systems Biology, 9052 Ghent, Belgium;6. Department of Botany, Faculty of Sciences, University of British Columbia, Vancouver V6T 1Z4, Canada;1. Chemical Optosensors and Applied Photochemistry Group (GSOLFA), Department of Organic Chemistry, Faculty of Chemistry, Complutense University of Madrid, 28040 Madrid, Spain;2. Chemical Optosensors and Applied Photochemistry Group (GSOLFA), Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, 28040 Madrid, Spain;3. CEI Campus Moncloa, UCM-UPM, Avda. Complutense s/n, 28040 Madrid, Spain |
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| Abstract: | Acetylcholinesterase and pseudocholinesterase activities were demonstrated in adult Schistosoma haematobium, S. mansoni, and S. rodhaini with wide-spectrum substrates associated with specific inhibitors. Only acetylcholinesterase activity was detected in the free-living larval stages. The results were confirmed by using specific substrates. No nonspecific esterases were detected. The specific inhibitor of mammalian acetylcholinesterase, 62C47, was only partially inhibitory to the parasite enzyme. |
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