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Synthesis and structure activity relationship of guanidines as NPY Y5 antagonists |
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| Authors: | Aquino Christopher J Ramanjulu Joshi M Heyer Dennis Daniels Alejandro J Palazzo Fabio Dezube Milana |
| Affiliation: | Department of Medicinal Chemistry, GlaxoSmithKline, RTP, NC 27709, USA. cja9377@gsk.com |
| Abstract: | A series of bis-aryl substituted guanidines have been discovered as potent NPY Y5 antagonists. The SAR and in vitro metabolic stability of these compounds are discussed. |
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