Metabolism of 1-O-alkyl-2-acetyl-sn-glycerol by washed rabbit platelets: formation of platelet activating factor |
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| Authors: | K Satouchi M Oda K Saito D J Hanahan |
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| Affiliation: | 1. Department of Medical Chemistry, Kansai Medical School, Moriguchi, Osaka 570, Japan;1. Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78284 USA |
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| Abstract: | A new type of neutral lipid, 1-O-alkyl-2-acetyl-sn-glycerol (AAG), induced a delayed aggregation pattern on interaction with washed rabbit platelets. Although far less potent on a molar basis than platelet activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine, AGEPC, nevertheless this compound caused an aggregation, albeit delayed in time, remarkably similar to that exhibited by AGEPC. In view of the possible formation of AGEPC in this reaction, AAG was incubated with washed rabbit platelets, and a lipid corresponding in chromatographic behavior to AGEPC was isolated and identified as such by a combined gas-liquid chromatography/mass spectrometry technique coupled with selected ion monitoring. |
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| Keywords: | To whom correspondence should be addressed. |
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