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Anti-HIV-1 peptides derived from partial amino acid sequences of CC-Chemokine RANTES |
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| Authors: | Yasuhiro Nishiyama Tsutomu Murakami Suguru Shikama Keisuke Kurita Naoki Yamamoto |
| Institution: | a Chemical Immunology and Therapeutics Research Center, Department of Pathology and Laboratory Medicine, University of Texas-Houston Medical School, 6431 Fannin, Houston, Texas 77030, USA b Department of Molecular Virology, Tokyo Medical and Dental University School of Medicine, Bunkyo-ku, Tokyo 113-8519, Japan c Department of Applied Chemistry, Faculty of Engineering, Seikei University, Musashino-shi, Tokyo 180-8633, Japan |
| Abstract: | Fifteen acetyl-peptide-amides with partial amino acid sequences of RANTES (regulated upon activation, normal T-cell expressed and secreted), all Cys residues of which were substituted by Ala, were synthesized, and screened for anti-HIV-1 activity. Peptides corresponding to 1–10, 37–46, and 57–68 showed marked activity against CC-chemokine receptor 5-using HIV-1JR-CSF (% inhibition at 100 nM 69, 82, 76%, respectively). The results indicate that multiple regions, including the N-terminal part responsible for chemotactic activity, are involved in anti-HIV-1 activity of RANTES, yielding possible lead compounds for anti-HIV-1 agents. |
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