| 肉毒毒素研究进展 |
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| 引用本文： | 朱力,王恒樑,黄留玉. 肉毒毒素研究进展[J]. 生物技术通讯, 2005, 16(2): 186-190 |
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| 作者姓名： | 朱力 王恒樑 黄留玉 |
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| 作者单位： | 军事医学科学院,生物工程研究所,北京,100071 |
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| 摘 要： | 肉毒毒素是肉毒梭菌产生的一种神经毒素,能够通过抑制神经肌肉接头处的乙酰胆碱释放而引起肌肉麻痹.肉毒毒素在培养液中以复合物形式存在,其中的毒性组分由3个非同源性结构域组成,是一种新型的金属蛋白酶.不同血清型的肉毒毒素能够特异性地作用于不同底物,这些底物在神经细胞的胞外分泌过程中发挥重要作用.肉毒毒素在胞吞胞吐机制的研究以及临床医学应用方面具有宝贵的价值.
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| 关 键 词： | 肉毒梭菌 肉毒毒素 结构 功能 神经毒素 胞吞胞吐机制 |
| 文章编号： | 1009-0002(2005)02-0186-05 |
| 修稿时间： | 2004-08-06 |
Progress in the Study of Botulinum Toxin |
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| ZHU Li,WANG Heng-Liang,HUANG Liu-Yu. Progress in the Study of Botulinum Toxin[J]. Letters in Biotechnology, 2005, 16(2): 186-190 |
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| Authors: | ZHU Li WANG Heng-Liang HUANG Liu-Yu |
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| Affiliation: | ZHU Li,WANG Heng-liang,HUANG Liu-yuInstitute of Biotechnology,Academy of Military Medical Sciences,Beijing 100071,China |
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| Abstract: | Botulinum toxins produced by Clostridium botulinum are neurotoxins and cause flaccid paralysis as a result ofinhibition of acetylcholine release at the neuromuscular junction. Botulinum toxins are produced in culture as molecular complexes consisting of non-toxic components and toxic Bonts, which form a new group of metalloproteinase composed of three nonhomologous domans. Bonts of different serotypes specificly cleave at different substrates, which play central roles in neuroexocytosis. Bonts will be of great value in the unravelling of the mechanisms of exocytosis and endocytosis, as they are in the clinical treatment. |
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| Keywords: | Clostridium botulinum botulinum toxin structure function |
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